"Ron Engels" wrote:
It's a standard frame (Pinarello Prince SL) with all the parts selected
and adjusted to fit me. That means according to the measuring system they
use. I'm quite happy with the bike as a whole, this is the only thing I'd
like to see improved.

http://www.pilotswatch.nl/images/pinarello/IMG_1607.jpg

From the picture, it looks to me like the saddle might be tilted downward
just a bit. If so, that will definitely put extra pressure on your hands.
Check it with a bubble level. I'd also tilt the bars up a couple of degrees
(and personally, I'd also get rid of the "anatomic" bars.)

Art