The Banana King and the Communist Cycling Group.

On Sat, 21 Mar 2020 12:16:35 -0500,
AMuzi wrote:
On 3/21/2020 11:46 AM, jbeattie wrote:
On Saturday, March 21, 2020 at 7:29:33 AM UTC-7, Tom Kunich wrote:

Where in God's name did you get the idea that Chloroquine is
particularly dangerous? Most drugs in overdoes quantities are
dangerous but that particular drug is used every single day
in rather large doses by arthritics, those with lupus and it
is even used on infants with other types of corona virus
infections.

Please don't parrot some moronic leftist crap since the
suggested dosage for a two week course is virtually harmless
unless someone has a rare and sensitive allergy to it.

Moronic leftist crap like the PDR?
https://www.pdr.net/drug-summary/Chl...hate-3418.2640

As an aside, many drug treatments for rheumatoid arthritis are
nasty and basically chemotherapy, e.g. methotrexate.

Yup.


The regimen is cloroquine with azithromycin, well studied for
malaria: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632633/

May be indicated for Chinese Wuhan virus. That will be studied
promptly for effectiveness because safety is not an issue to
regulators (safety being the first hurdle to approval).

Mostly true, although there may be some need to look at safety if
the prevalent comorbities and disease effects don't align well.

--
Ted Heise West Lafayette, IN, USA

On Sat, 21 Mar 2020 12:41:47 -0700, Tom Kunich wrote:


I have to take a couple of antiseizure medications because of the
concussion. So I have to have at least one and usually two blood tests a
year to measure blood levels of these chemicals. Too high a level will
kill me so I am rather sensitive to knowing the what and why of dosages.

Err, twice a year is nothing more than routine monitoring of the elderly
over here. It would be monthly blood tests if they were watching blood
leves closely for ossible side effects.

The two week treatment of this is at the moment 2/3rds the level of
daily treatment for Lupus. What's more, it is also used as a treatment
in infants for another type of corona virus.

Are you fully cognisent with the various amount prescribed. soe time the
amoung of active drug can be orders of magntude difference.

Is this medication dangerous if overdosed? Probably - try having a
couple of drinks and 5 aspirin tablets of the "instant release" variety.

Hint, only swallowed dissolved asprin. It is chugging whole tablets that
eats hles in your stomach.

On Sat, 21 Mar 2020 13:18:45 -0500,
AMuzi wrote:
On 3/21/2020 12:49 PM, Ted Heise wrote:
On Sat, 21 Mar 2020 12:16:35 -0500,
AMuzi wrote:

The regimen is cloroquine with azithromycin, well studied
for malaria:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632633/

May be indicated for Chinese Wuhan virus. That will be
studied promptly for effectiveness because safety is not an
issue to regulators (safety being the first hurdle to
approval).

Mostly true, although there may be some need to look at safety
if the prevalent comorbities and disease effects don't align
well.

I defer to you.
I have a brother who's a medical research scientist so I know
enough to know that I don't know.

Well, that's very gracious, but it occurred to me after I posted
that such possible effects would quite likely be evaluated in the
postmarket in these circumstances.

--
Ted Heise West Lafayette, IN, USA

On Sunday, March 22, 2020 at 6:46:48 AM UTC-7, Ted Heise wrote:
On Sat, 21 Mar 2020 13:18:45 -0500,
AMuzi wrote:
On 3/21/2020 12:49 PM, Ted Heise wrote:
On Sat, 21 Mar 2020 12:16:35 -0500,
AMuzi wrote:

The regimen is cloroquine with azithromycin, well studied
for malaria:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632633/

May be indicated for Chinese Wuhan virus. That will be
studied promptly for effectiveness because safety is not an
issue to regulators (safety being the first hurdle to
approval).

Mostly true, although there may be some need to look at safety
if the prevalent comorbities and disease effects don't align
well.

I defer to you.
I have a brother who's a medical research scientist so I know
enough to know that I don't know.

Well, that's very gracious, but it occurred to me after I posted
that such possible effects would quite likely be evaluated in the
postmarket in these circumstances.

--
Ted Heise West Lafayette, IN, USA

Well, we have a long history of application of this medication so I don't believe that comorbities is a question, do you? If I understood it correctly the dosage for Lupus was something like 10 mg/kg of body weight and treatment for the coronavirus was 7.8 mg/kg.

On Sunday, March 22, 2020 at 9:14:45 AM UTC-7, Tom Kunich wrote:
On Sunday, March 22, 2020 at 6:46:48 AM UTC-7, Ted Heise wrote:
On Sat, 21 Mar 2020 13:18:45 -0500,
AMuzi wrote:
On 3/21/2020 12:49 PM, Ted Heise wrote:
On Sat, 21 Mar 2020 12:16:35 -0500,
AMuzi wrote:

The regimen is cloroquine with azithromycin, well studied
for malaria:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632633/

May be indicated for Chinese Wuhan virus. That will be
studied promptly for effectiveness because safety is not an
issue to regulators (safety being the first hurdle to
approval).

Mostly true, although there may be some need to look at safety
if the prevalent comorbities and disease effects don't align
well.

I defer to you.
I have a brother who's a medical research scientist so I know
enough to know that I don't know.

Well, that's very gracious, but it occurred to me after I posted
that such possible effects would quite likely be evaluated in the
postmarket in these circumstances.

--
Ted Heise West Lafayette, IN, USA

Well, we have a long history of application of this medication so I don't believe that comorbities is a question, do you? If I understood it correctly the dosage for Lupus was something like 10 mg/kg of body weight and treatment for the coronavirus was 7.8 mg/kg.

Uh, comorbidities are always a question. "Comorbidities" means "the simultaneous presence of two chronic diseases or conditions in a patient." You are misusing the term and apparently mean "side-effects" or "adverse reactions."

In connection with the virus, comorbidities associated with poor outcomes include pulmonary impairment, hypertension and heart disease.

Adverse reactions to Chloroquine are well known and listed in the PDR. https://www.pdr.net/drug-summary/Chl...hate-3418.2640 There are also potential drug interactions.

No need to guess at this. Actual, trained professions are on the job.

-- Jay Beattie.

On 3/22/2020 1:04 PM, jbeattie wrote:
On Sunday, March 22, 2020 at 9:14:45 AM UTC-7, Tom Kunich wrote:
On Sunday, March 22, 2020 at 6:46:48 AM UTC-7, Ted Heise wrote:
On Sat, 21 Mar 2020 13:18:45 -0500,
AMuzi wrote:
On 3/21/2020 12:49 PM, Ted Heise wrote:
On Sat, 21 Mar 2020 12:16:35 -0500,
AMuzi wrote:

The regimen is cloroquine with azithromycin, well studied
for malaria:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632633/

May be indicated for Chinese Wuhan virus. That will be
studied promptly for effectiveness because safety is not an
issue to regulators (safety being the first hurdle to
approval).

Mostly true, although there may be some need to look at safety
if the prevalent comorbities and disease effects don't align
well.

I defer to you.
I have a brother who's a medical research scientist so I know
enough to know that I don't know.

Well, that's very gracious, but it occurred to me after I posted
that such possible effects would quite likely be evaluated in the
postmarket in these circumstances.

--
Ted Heise West Lafayette, IN, USA

Well, we have a long history of application of this medication so I don't believe that comorbities is a question, do you? If I understood it correctly the dosage for Lupus was something like 10 mg/kg of body weight and treatment for the coronavirus was 7.8 mg/kg.

Uh, comorbidities are always a question. "Comorbidities" means "the simultaneous presence of two chronic diseases or conditions in a patient." You are misusing the term and apparently mean "side-effects" or "adverse reactions."

In connection with the virus, comorbidities associated with poor outcomes include pulmonary impairment, hypertension and heart disease.

Adverse reactions to Chloroquine are well known and listed in the PDR. https://www.pdr.net/drug-summary/Chl...hate-3418.2640 There are also potential drug interactions.

No need to guess at this. Actual, trained professions are on the job.

Are you suggesting we should pay attention to trained professionals,
instead of to a bitter, brain damaged, unemployed right wing Usenet troll?

Sorry. I forgot to "reset."

--
- Frank Krygowski